Ketcher Web-based chemical structure drawing software

New features

• #6215 – Introducing the snap to angle and standard bond length for monomers connected via bonds
• #6252 – Allow creation of antisense chains in sequence mode
• #6383 – Introduce the creation of DNA antisense chains
• #6355 – Change attachment points of backbone monomers in automatically created antisense chains
• #6254 – Update the representation of sense and antisense chains in sequence mode (2/2)
• #6284 – Long bonds for uneven double stranded sequences in snake and flex modes
• #6527 – Add ability to pass coordinates to Ketcher addFragment and setMolecule API to position provided structure
• #6357 – Allow insertion of phosphates (p) from the keyboard in sequence mode
• #6596 – Update Indigo to 1.30.0 in browser module

Bugfixes and improvements

• #6219 – Unable to save to HELM hydrogen connection between micromolecule (with AP) and monomer
• #6005 – Move the dot indicating a modified phosphate in sequence mode
• #4145 – Implement popup versions of Ketcher (and routing)
• #5700 – System allows to establish infinite number of bonds from monomer to microstructure
• #6534 – Adding nucleotide to the last position having phosphate in antisense causes exception: ReferenceError: process is not defined
• #6402 – Hydrogen bonds misaligned due to antisense strand direction change when opening or pasting a structure in Macro Mode
• #6464 – Splitting chain with Enter key doesn't work
• #6425 – Hiding of number indicators while in sync editing mode when the triangle overlaps with the number
• #6535 – Unable to add nucleoside to the end of sequence if hanging antisense monomer present
• #6561 – Switching to macromolecules changes CSS in the page
• #6369 – System doesn't switch Library tab to proper one if user changes typing type using keyboard shortcuts
• #6627 – Fix invisible snapping drawings after switching to micro mode
• #6621 – Fix monomer snapping wiping monomer labels
• #6608 – API setMolecule moves molecule off-canvas on second call
• #6607 – README missing coordinate units for setMolecule and addFragment API methods
• #6539 – System should add same thing in antisense chain but not connect it with H-bond if it is not nucleotide/nucleoside
• #6624 – Enter key in single-strand edit mode incorrectly breaks both chains instead of only one
• #6632 – New sequence appears gray after clearing the canvas in non-sync mode
• #6631 – Sync mode causes incorrect letter input after adding a monomer in non-sync mode
• #6606 – Adding nucleotide to the last position having phosphate in antisense works wrong
• #6531 – System can't add nucleotide between phosphate and nucleotide in antisense chain
• #6617 – Empty element appears after undoing line deletion in Sequence mode and switching to Flex/Snake mode
• #6609 – System creates ambiguous RNA nucleotides instead of DNA ones in case of DNA antisense stand creation
• #6615 – Missing warning message when deleting all hydrogen bonds between two chains
• #6619 – System doesn't create antisense phosphate if it situated to the left from nucleotide
• #6623 – Sense and antisense chains switch places during editing based on monomer count
• #6443 – System allows to select single antisense symbol that causes an error if it got deleted
• #4002 – getSmiles and getSmarts on query feature containing aromatic ring raises an error
• #6709 – Unable to paste HELM from clipboard to the canvas. System throws an error: Convert error! option manager: Property "sequence-type" not defined
• #6723 – Forbid moving sequence nodes and snapping by select rectangle tool
• #6729 – Create RNA/DNA Strand doesn't work for B, K, Y and S ambiguous bases
• #6750 – Incorrect R1 attachment atom for natural Ribose (R) in the library
• #6759 – Add pruning of the remaining transient views on clear canvas button click
• #6795 – Incorrect properties of some monomers in the library
• #6829 – Add monomers to the library
• #6786 – Add monomers from HELM Core Library to Ketcher Library

New features

• #6167 – Long bonds for linearly displayed circular structures
• #5942 – Update the representation of sense and antisense chains in sequence mode (1/2)
• #5995 – Synchronize the library tab with typing type switcher in sequence mode
• #6222 – New chain tool behavior
• #6246 – Import indigo with EXPORT_ES6 & USE_ES6_IMPORT_META options
• #6417 – Update Indigo to 1.29.0 in browser module

Bugfixes and improvements

• #6164 – Changing any parameter at Settings cause Undo/Redo work wrong (or delete undo history)
• #6166 – Color schema for Favorites tab at RNA Library is wrong for Peptides
• #6088 – Disable create antisense strand option if antisense-less base present in chain selection
• #5696 – Adding Attachment point to microstructure already connected to monomer - causes problems
• #6201 – Circular hydrogen bond connection between three (or more) chains, those hydrogen bonds isn't considered as side chain connection for layout purposes
• #6195 – Nucleotide wrongly become antisense oriented if have hydrogen connection to sugar
• #6194 – Unknown monomer and CHEM overlap to each other if both are the side chain for same chain
• #6422 – Long bond appears behind monomers when using attachment points
• #6084 – System doesn't allow select ambiguous monomers from the library
• #6085 – Changing of ambiguous base via RNA Builder on Sequence mode causes sequence corruption
• #6098 – Adding second chain with antisense chain to the canvas cause layout problem
• #6446 – System shouldn't merge two antisense chains if separator monomer got deleted
• #6447 – System doesn't split chain pair on two if - symbol deleted
• #6460 – Troubles with switching to Edit mode if - symbol present in sequence
• #5780 – Connection points appear visually disconnected when moving monomers in Flex and Snake mode
• #6462 – Adding peptide between RNA and - symbol breaks sense/antisense chain
• #6456 – Long bond appears behind the structure after Copy-Paste in Flex Mode
• #6471 – Removing peptide from sense/antisense chain cause unnecessary phosphate removal
• #5780 – Connection points appear visually disconnected when moving monomers in Flex and Snake mode
• #6493 – Undo of deleted bond on sequence mode causes "ghost" monomer appearance on the canvas
• #6505 – Hotkey CTRL+ALT+P does not switch library to Peptides
• #6628 – Add export of ketcher-standalone esm module as cjs
• #6159 – Aromatizing doesn't work for Pyridone and Pyrone (molecules from Template library)
• #6588 – Peptide sequence not pasting directly on canvas
• #6661 – Adjust ketcher-standalone entrypoints to work for all builders

New features

• #6034 – Make macromolecules switcher enabled by default
• #6029 – Enter flex mode when macromolecules mode was not entered in before and there is a drawing on canvas
• #6027 – Support for single atom properties in macromolecules mode
• #6028 – Support all remaining types of bonds from small molecules mode in macro molecules mode
• #6227 – Update indigo to 1.28.0 in browser module

Bugfixes and improvements

• #5978 – Entire element bounding box should be clickable, not only black dots
• #6127 – Hover mouse over ambiguous monomer on Micromolecules canvas causes app crash
• #5476 – Copy/Cut and Paste using Ctrl+C/X and Ctrl+V doesn't work for static elements in Mozilla Firefox
• #5317 – Some side chain bonds are not shown in Sequence mode for bases, CHEMs, phosphates and sugars
• #5796 – Indigo functions doesn't work if monomer on micro canvas - system throws an error: Error: Cannot deserialize input JSON.
• #5032 – Selection of monomers should disappear when the user moves the cursor
• #5139 – After pressing the Clear Canvas button in sequence-editing view, the Enter button does not start a new sequence but erases it
• #5231 – Canvas should remain in edit mode if we insert monomer from the library
• #5795 – Undo operation doesn't work for monomer at micro mode if it was deleted - system throws exception in console
• #6112 – System opens "intellisence"-like dropdown control in unnecessary case
• #5663 – Movement of microstructures on Sequence mode doesn't work
• #4533 – After inserting a nucleotide in the Text-editing mode, the cursor blinks in the wrong place
• #6026 – Bond length is different for monomers loaded from HELM and from the library
• #4723 – When pressing Enter, a user can create new sequences in the “Modify RNA Builder” mode
• #6022 – Side chain attachment point shown in wrong place in Snake mode
• #5341 – Replacing all monomers (or part of them) in edit mode - works wrong - system cuts sequence on two
• #5670 – Structural distortion occurs during multi expand and multi collapse of macromolecule abbreviations in micro mode
• #6021 – Connection between molecule and monomer does not affect an amount of implicit hydrogens
• #5115 – Switching from Sequence mode to Flex mode and back shifts visible area of canvas beyond visible frame.
• #4526 – In the Text-editing mode, the canvas is not moved to make the newly added sequence visible
• #6240 – Export to 3-letter sequence doesn't work
• #6235 – Incorrect representation of hydrogens for alias charge valence and radical properties in macro mode
• #6034 – Combine two editors in ketcher-react package in order to make macro switcher enabled by default
• #6247 – Update the help document
• #3627 – Ketcher requires unsafe-eval in order to run, which contradicts content security policy best practices
• #6344 - Excessive scroll appears in macromolecules mode in canvas if Ketcher is inside dialog window
• #6291 - Super G and Super T monomers do not load from a saved RXN V3000 file
• #6370 - Inconsistent zoom behavior when inserting a molecule via setMolecule and Paste from Clipboard/Open from File
• #6375 - Ketcher renders editor twice in dev mode
• #6379 - Ketcher does not respond if switch to macromolecules, close popup with ketcher and open again
• #6411 - Ketcher structure copy-paste in KET instead of MOL
• #6196 - Ambiguous DNA bases (N, D, H, W) wrongly converted to DNA bases on antisense creation
• #6106 - Two sense chain to one antisense connection render
• #6272 - Cursor position after adding preset in sequence mode causes an incorrect sequence formation
• #6132 - System should not re-layout canvas in case of antisense creation

New features

• #5678 - Introduce creating antisense chains
• #5925 - Layout for antisense chains in sequence mode
• #5712 - Update snake layout logic taking into account hydrogen bonds
• #5990 - Extend Ketcher API to allow updating monomers library
• #5630 - Mark all modified monomers on canvas (flex and snake modes)
• #5629 - Mark modified amino acids on canvas in sequence mode
• #5854 - Add "Copy to Clipboard" to the export window
• #5618 - Ketcher doesn't trigger change event in macromolecule mode
• #5515 - Add ketcher calculate values API
• #6008 - Update indigo to 1.27.0 in browser module

Bugfixes and improvements

• #5873 - Export to ket (and getKET function) change incrementally internal IDs every call
• #5270 - Warning should not displayed for importing CDXML, base64 CDX
• #5351 - Inform User to Apply Layout after Settings Adjustment
• #5931 - Copy/Cut-Paste functionality not working for microstructures in Macro mode
• #5982 - Label shift problem for ambiguous monomers
• #5954 - The reaction with catalysts is displayed incorrect with ACS style setting and after layout
• #4352 - Gap between button and drop-down list of Macro modes
• #5855 - System reset micromolecule canvas settings to default if switched to Macro mode and back
• #5974 - Paste to canvas recogniton logic should be changed
• #3813 - Page auto jump to top when ketcher editor inited
• #5988 - Exception when modifying a functional group after adding a Ketcher editor subscription
• #6068 - Same chain configuration imported by different HELM layouted differently (anyway - both are wrong)
• #6089 - Antisense creation doesn't work for the chain if not eligable base present in other chain presented in selection
• #6061 - RNA chain remain flipped after hydrogen bond removal
• #6067 - Two chains connected by H-bond arranged wrong if third bond present on the canvas
• #6070 - System doesn't flip chain if connected to monomer but not to base
• #6074 - System doesn't flip chain if connected to monomer but not to base (2)
• #6080 - System doesn't flip chain if connected to monomer but not to base (3)
• #6075 - In case of multipal H-bonds system should arrange antisence chain to first base of bottom chain
• #6076 - Two-to-one base H-bond connection layouted wrong
• #6077 - H-bond is not alligned to Snake mode view in some cases
• #6081 - Smaller chain should be at the bottom
• #6087 - Antisense layout is wrong for any ambiguouse base from the library
• #6097 - System creates antisense chain only for top chain if many of chains selected
• #6102 - System keeps antisense base layout and enumeration even after chain stops being antisense (and vice versa)
• #6105 - Layout works wrong if bases of the same chain connected by H-bonds
• #6086 - Unable to create antisense chains for ambiguous monomers from the library
• #6107 - Create Antisense Strand doesn't work in some cases
• #6096 - Antisense creation works wrong in case of partial selection
• #6109 - Antisense of layout doesn't work on flex mode after load
• #6083 - Creation of antisense chain causes monomer re-arrangement on the flex canvas
• #6115 - Lets get back to U (instead of T) for the complementary base of A
• #6129 - Undo operation creates unremovable bonds on the canvas (clear canvas doesn't help)
• #6161 - Stereo flags are displayed despite enabling 'Ignore chiral flag' in MOL V2000 files
• #6185 – Make SGroups expandable while placed within a chain

New features

• #5354 – Apply new hash spacing setting to canvas
• #5579 – Introduce Hand tool for macromolecules mode
• #5590 – Zoom in macromolecules mode should be in relation to the top left corner of the structures
• #5403 – Introduce hydrogen bonds in macromolecules mode
• #5600 – Zoom in automatically upon import of small sequences
• #5637 – Display hydrogen in atom label for molecules in macromolecules mode
• #5556 – Allow import and export of sequences with three letter amino acid codes
• #5640 – Multiple monomers expansion in micro molecules mode
• #5187 – Introduce new amino-acid colors
• #6174 – Update indigo to 1.26.0 in browser module

Bugfixes and improvements

• #5370 – System should remember the canvas mode on Molecules/Macromolecules mode switch (do not switch to Sequence by default)
• #5372 – Toggling between Flex and Sequence modes causes losing layout info
• #5564 – Search of ambiguous monomers doesn't work
• #4475 – Numbers on top of letters are not centered
• #4936 – Applying Enhanced Stereochemistry to monomers causes it to disappear from the canvas (and exception in console)
• #4941 – System shows Edit S-Group option for every bond of molecule if it has attachment point
• #5181 – getKet duplicates items when macro molecules are use
• #5398 – Elliptic arrow icons order is wrong at arrow toolbar
• #5935 – Unable to establish hydrogen bond connection if monomer has no free attachment points
• #5941 – Hydrogen bonds remain in place on monomer delete
• #5940 – Copy/paste operation works wrong (copy only two hydrogen bonds and drops others)
• #5933 – Error message is wrong if user tries to establish hydrogen bond if it already exists
• #5967 – System should not change monomer position after switching from Molecules to Macromolecules - Sequence
• #5972 – Export to three letter amino acid codes cause convert error
• #5969 – Load from file having only microstructures on macro canvas causes unnecessary zoom up to 200% and shift molecule to top left angle
• #5970 – Unable to connect monomer to molecule in snake mode
• #5949 – Delete of micro molecules bonds works wrong (or doesn't work)
• #5910 – Fix closest sgroup detection to allow focusing on entities within expanded monomer's bounding box

Github link: https://github.com/epam/ketcher/releases/tag/v2.27.0

New features

• #5400 – Expand macromolecules in micro mode
• #5359 – Display molecules in macro mode: basic structures with atoms and bonds
• #5325 – Change natural analogue of monomers
• #5324 – Change symbols of monomers
• #5323 – Change names of monomers
• #5195 – Some content problems in monomer library
• #5111 – Change structure of monomers
• #4984 – Highlight atoms and bonds
• #4965 – View only mode
• #4986 – Ctrl+move copy
• #1838 – Create custom top toolbar buttons
• #5156 – Add new option in settings ACS style
• #5154 – Change "Double bond width" setting
• #5175 – Allow entering values in settings with the precision of one decimal place
• #4982 – Choose both directions of wedged/hashed bonds from right-clicking the bond
• #5435 – Change bond length for ACS styles settings
• #5351 – Change the default size of a plus and the arrows
• #5945 – Update indigo to 1.25.0 in browser module

Bugfixes and improvements

• #5430 – Fix ESLint error in selectClearCanvasTool function
• #4983 – Settings for the "attachment point tool" don't update with changed pixel settings
• #4757 – Incorrect stereo-label placement for (E) and (Z)
• #5536 – White screen is displayed after change direction of wedge bond
• #5296 – Save Support for RDF Format
• #5615 – Overlapping UI elements in Query Properties right-click menu
• #4394 – In the Sequence mode, the tooltip “Start new sequence” is shown outside of the canvas
• #5651 – The reaction can't save to MDL RXN V3000 (returns RXN V2000 instead)
• #5597 – New rendering for highlight
• #5561 – Set a new name for the button ACS style
• #5672 – Multiple duplicate items
• #5205 – Edit Connection points dialog can cause invalid connection between monomers
• #5709 – Unable to load variant sugar from HELM - system throws an error: Convert error! {}
• #5710 – Unable to load variant phosphate from HELM - system throws an error: Convert error! {}
• #5711 – Unable to load variant CHEM from HELM - system throws an error: Convert error! {}
• #5621 – O and U symbols are not supported in sequence mode
• #5612 – The file size is the same when saved to PNG
• #5634 – ketcher.getMolfile() stopped working for macro canvas with peptides
• #5649 – Default values for bond settings (at least for bond) got corrupted and become wrong after 2.26 version installed
• #4316 – In the Sequence and Flex mode the nucleotide preview is closely adjacent to the left edge of the screen
• #5557 – Bond/monomer tooltip preview placed wrong in on edge cases
• #5097 – Selection frame is displayed improperly for overlapped images
• #5148 – Image changes the layer to top after scaling actions
• #5581 – If switch to View Only Mode with Fragment Selection you cannot change or select another selection mode
• #5657 – Clear canvas doesn't work for microstructures on macro mode
• #5679 – Unable to establish connection between microstructure and macro-ones
• #5401 – Side-chain connections are not displayed in Snake mode
• #5662 – Fix inability to select Erase tool after monomer expansion
• #5612 – The file size is the same when saved to PNG
• #5686 – Bonds between micro and macro structures couldn't be selected and deleted
• #5659 – Moving of selected microstructures on macro canvas works wrong
• #5665 – Show remove abbreviation dialog when trying to erase expanded monomer
• #5725 – Cursor position is incorrect when editing sequence in Macro mode
• #5800 – Application crashes with white screen in Macro mode when loading local storage data from a previous version
• #5758 – Highlight only bonds when selected bonds + atoms
• #5703 – Added tooltip for image resolution option
• #5673 – Microstructures connected to polymer chains are not shown on Sequence mode canvas
• #5650 – The reaction with catalysts is displayed incorrect with ACS style setting and after layout
• #5761 – Fix minimal distances for multi-tail validation in KET format
• #5413 – Can't add specific SVG image to Canvas in Mozilla Firefox
• #5434 – Document creation and behavior of custom buttons
• #5776 – Add API Method getRdf for retrieving RDF representation of structures
• #5786 – Uncaught TypeError is in console when trying to move tail of Multi-Tailed Arrow added from KET with small size between tails
• #5753 – Issue with moving of tail of multi-tailed arrow with several tails when user needs to move the tail close to another one
• #5679 – Unable to establish connection between microstructure and macro-ones
• #5848 – Unable to establish connection between microstructure and sugar or phosphate (and partially - unresolved monomer)
• #5703 – The picture is incorrect when image resolution high and bond thickness changing
• #5685 – The diagonal bond in the molecule is displayed incorrect with ACS style
• #5674 – Inconsistent behavior of copy-paste and cut-paste operations with macromolecule abbreviations
• #5658 – Incorrect selection behavior when using Selection tool on Macromolecule abbreviations
• #5699 – After bulk deletion of monomer abbreviations, Undo returns expanded monomers
• #5836 – R-Group fragment labels font size isn’t defined by Sub Font size property at Settings
• #5834 – S-Group (Data type) Field value label font size uses Settings - Font size property value instead of Sub font size one
• #5833 – Importing functional groups (e.g., Boc, Bn, CF3) ignores drawing settings (e.g. ACS style)
• #5809 – System opens wrong context menu for monomers on micro canvas if clicked on atom or bond
• #5887 – After save and load a MOL V3000 file in macro and micro mode, bond connections are changed, and the microstructures are shifted
• #5814 – On Remote environment, the reaction/molecule can't be saved to V3000 formats (returns V2000 instead): MOL, RXN, SDF, RDF
• #5886 – Loading a KET file in macro mode, bond connections are preserved but microstructures are shifted

Github link: https://github.com/epam/ketcher/releases/tag/v2.26.0

New features

• #4884 – Implement preview display for monomer bonds
• #4554 – Support ambiguous monomers in Ketcher (flex mode)
• #4556 – Support of ambiguous monomers in sequence view
• #4557 – Support of ambiguous monomers in small molecules mode
• #5186 – Add ambiguous monomers to the library and allow their addition to the canvas
• #4555 – Preview for ambiguous monomers
• #5224 – Implement preview in connection modal for ambiguous monomer
• #4872 – New approach and UI for switching between types in sequence mode
• #4861 – Introducing multi-tail arrows
• #4985 – Support retrosynthetic arrows
• #4853 – Search monomer in library by IDT
• #4926 – Add IDT alias to chem monomer
• #5244 – Add CHEMs to the library
• #5264 – Add amino acids to the library
• #5152 – Add new settings for ACS style
• #5560 – Update Indigo to 1.24.0 in browser module

Bugfixes and improvements

• #5200 – The user’s choice is not saved in the settings but is recalculated in px
• #4658 – Some bonds remain selected on export to SVG in Snake mode
• #5201 – it is not possible to enter a value when selecting cm inch pt manually in the settings
• #5454 – Export of variant monomers to Sequence/FASTA doesn't work for presets
• #5425 – Undo-Redo operations over ambiguous monomer causes broken canvas
• #5464 – Undo operation removes ambiguous monomer from the canvas but keep in the KET file export
• #5209 – Cancel of Edit Connection points dialog cause existed connection points eliminated
• #5453 – Circle with monomer number should be few pixels down
• #5427 – Preview tooltip for mixture ambiguous monomer shows wrong percentages
• #5466 – HELM inline SMILES monomer canvas color is wrong
• #5470 – Export of different mixed and alternatives peptides (with different proportions and percents) works wrong
• #5313 – Creation preset without phosphate causes R3-less sugars disabled in the library
• #5447 – Added fixed precision class, updated multi-tail calculations with fixed precision usage
• #5368 – An error appears in the Console, when dragging a bond between any monomers
• #4212 – Limit size of structures in preview
• #5473 – Export of different mixed and alternatives RNAs (with different proportions and percents) works wrong
• #5465 – Export of different mixed monomers (with different ratios) works wrong
• #5512 – System saves mixture ambiguous monomers as alternatives ambiguous monomers
• #5519 – Alias labels for mixed bases loaded from IDT are wrong
• #5521 – Sugar color is wrong if loaded from HELM with inline SMILES
• #5545 – After uploading a multi-character monomer in HELM format, abbreviations in sequence mode are cluttered together

Github: https://github.com/epam/ketcher/releases/tag/v2.25.0

New features

• #4878 – Add/Replace monomer in sequence mode from library
• #4880 – Adjust previews – add APs, show IDT aliases for previews in sequence mode, increase debounce time
• #4888 – Enable editing sequences by click between symbols
• #4887 – Starting new sequences with "Plus" icon on canvas
• #4780 – Remove monomers from the library (Peptides and CHEMs)
• #5167 – Change natural analogue of monomers Peptides and CHEMs)
• #4787 – Change structure of monomers (Peptides and CHEMs)
• #5166 – Change symbols of monomers (Peptides and CHEMs)
• #4781 – Change names of monomers (Peptides and CHEMs)
• #4905 – Open Edit Connection Points dialog via right click on bond
• #4911 – Insert image from ket to canvas
• #4897 – Insert image to canvas via "Add image" tool, Select, Move and Scale the image
• #4981 – Support for SSR
• #4979 – Support for Strict mode
• #5190 – Include Indigo without render module into ketcher-standalone build process
• #5284 – Update Indigo to 1.23.0 in browser module

Bugfixes and improvements

• #4763 – It is possible to create forbidden RNA preset
• #4962 – Bond tool and Erase tool buttons have to be disabled in Sequence mode (since they are not applicable)
• #4659 – Export result SVG contains some labels that are selectable
• #4108 – There are no tooltips when hovering over each of the sequence modes
• #4806 – It is allowed to change bond type between micro and macro
• #4936 – Applying Enhanced Stereochemistry to monomers causes its disappear from the canvas (and exception in console)
• #5090 – The favorites icon overlaps unsplit nucleotide names in the RNA and favorites tab
• #4947 – Distance between unresolved monomer and preview tooltip is too large and it has no IDT alias
• #4957 – Disabled query features in extended table not disabled in right-click menu
• #5126 – The error appears in the Console, when connecting two unsplit nucleotides in Snake mode
• #4069 – Right-click context menu protrudes beyond edges of the Ketcher workspace
• #4806 – It is allowed to change bond type between micro and macro
• #5196 – An error appears in the Console when opening any section in the RNA tab
• #5242 – Replace phosphate at the end with peptide causes cycled polymer
• #5184 – Fix unresolved monomers bond establishing issue
• #4935 – Enumeration is missing for cycled unsplit nucleotides after load from file (KET/MOL doesn't matter)
• #5255 – Fix adding new monomers to canvas in sequence mode while editing RNA in builder
• #5245 – Replacement of peptide at the end of sequence on preset w/out base works wrong
• #5228 – System insert monomer from the library to the canvas even if it shouldn't (and error message is wrong)
• #5300 – Attempt to insert improper monomer from the library to the sequence causes wrong error
• #5301 – New preset creation process interferes with monomer replacement on the sequence mode

GitHub: https://github.com/epam/ketcher/releases/tag/v2.24.0

New features

• #4852 – UX support for HELM import/export
• #4846 – Make Sequence view default in Macromolecules mode
• #4431 – Implement support of unresolved IDT monomers
• #4382 – Implement support of unsplit nucleotides
• #3532 – Displaying side chain connections in snake-like mode
• #4856 – Add new CHEM monomers to the library
• #2654 – Improve WASM loading performance
• #5083 – Update indigo to 1.22.0 in browser module

Bugfixes and improvements

• #4660 – Zero charge shows explicit 0 instead of blank after using A+/A- Tools
• #4801 – Cut operation for attachment points makes canvas inaccessible/unoperational and delete entire molecule
• #4636 – In the Sequence mode, when selecting elements on the canvas, the total number of elements is not displayed in the Right-click menu
• #4686 – After moving the structure in the Macro mode, in the Micro mode the S-group value is displayed separately from the structure
• #4823 – In sequence mode, each press adds two characters and when deleted, also removes two
• #4793 – Context menu for attachment point labels should contain only Delete option
• #4784 – Attachment point enumeration logic works wrong
• #4786 – Keyboard shortcut stops working after adding/removing attachment point
• #4607 – Inconsistent display of a separate phosphate in the sequence representation in the Sequence mode
• #4782 – It is possible to attach bond to attachment point label
• #4791 – System saves selection states of attachment point labels to KET file (it should not)
• #4837 – Library filter does not reset when switching between Micro and Macro mode
• #4833 – Support rendering multiple Ketcher editors on a page without an iframe
• #4773 – It is impossible to apply R-group to atom with attachment point attached
• #4927 – Able to change attachment point label to an atom if it is selected first
• #4925 – Unable to change atom to another if molecule has attachment point
• #4929 – System allows to change atoms inside S-group without removing abbreviation
• #4930 – Fix missing IDT aliases and label positioning for unsplit nucleotides
• #4889 – After using "Clear Canvas" in the Sequence mode and entering new sequence, extra structures are shown in Flex and Snake modes
• #4924 – RNA Preset without Base causes constant crash after switching to Macromolecules mode
• #4977 – System doesn't show side chain bonds if chain loaded directly to Snake-mode canvas
• #4997 – The second of three horizontal bond overlaps backbone connection line
• #4975 – Connection is displayed at the bottom of the row, if drag a horizontal side-chain connection between the extreme nucleotides of a row
• #5035 – Bonds in the snake chain are displayed differently after saving in ket format
• #5034 – When dragging the side chain connections between CHEM, all these connections pass exclusively from the left, and not the shortest path
• #4881 – When switching from Sequence mode to Flex mode, RNA abbreviations remain
• #4995 – The bottom horizontal bonds do not shift if there is an overlap
• #5074 – Switching from Sequence mode to Snake mode and back shifts visible area of canvas beyond visible frame. Forever.
• #5121 – Copy does not work in the Firefox browser
• #5335 - The application crashes when selecting Enhanced Stereochemistry from the right-click menu

GitHub: https://github.com/epam/ketcher/releases/tag/v2.23.0

New features

• #4852 – UX support for HELM import/export
• #4846 – Make Sequence view default in Macromolecules mode
• #4431 – Implement support of unresolved IDT monomers
• #4382 – Implement support of unsplit nucleotides
• #3532 – Displaying side chain connections in snake-like mode
• #4856 – Add new CHEM monomers to the library
• #2654 – Improve WASM loading performance
• #5083 – Update indigo to 1.22.0 in browser module

Bugfixes and improvements

• #4660 – Zero charge shows explicit 0 instead of blank after using A+/A- Tools
• #4801 – Cut operation for attachment points makes canvas inaccessible/unoperational and delete entire molecule
• #4636 – In the Sequence mode, when selecting elements on the canvas, the total number of elements is not displayed in the Right-click menu
• #4686 – After moving the structure in the Macro mode, in the Micro mode the S-group value is displayed separately from the structure
• #4823 – In sequence mode, each press adds two characters and when deleted, also removes two
• #4793 – Context menu for attachment point labels should contain only Delete option
• #4784 – Attachment point enumeration logic works wrong
• #4786 – Keyboard shortcut stops working after adding/removing attachment point
• #4607 – Inconsistent display of a separate phosphate in the sequence representation in the Sequence mode
• #4782 – It is possible to attach bond to attachment point label
• #4791 – System saves selection states of attachment point labels to KET file (it should not)
• #4837 – Library filter does not reset when switching between Micro and Macro mode
• #4833 – Support rendering multiple Ketcher editors on a page without an iframe
• #4773 – It is impossible to apply R-group to atom with attachment point attached
• #4927 – Able to change attachment point label to an atom if it is selected first
• #4925 – Unable to change atom to another if molecule has attachment point
• #4929 – System allows to change atoms inside S-group without removing abbreviation
• #4930 – Fix missing IDT aliases and label positioning for unsplit nucleotides
• #4889 – After using "Clear Canvas" in the Sequence mode and entering new sequence, extra structures are shown in Flex and Snake modes
• #4924 – RNA Preset without Base causes constant crash after switching to Macromolecules mode
• #4977 – System doesn't show side chain bonds if chain loaded directly to Snake-mode canvas
• #4997 – The second of three horizontal bond overlaps backbone connection line
• #4975 – Connection is displayed at the bottom of the row, if drag a horizontal side-chain connection between the extreme nucleotides of a row
• #5035 – Bonds in the snake chain are displayed differently after saving in ket format
• #5034 – When dragging the side chain connections between CHEM, all these connections pass exclusively from the left, and not the shortest path
• #4881 – When switching from Sequence mode to Flex mode, RNA abbreviations remain
• #4995 – The bottom horizontal bonds do not shift if there is an overlap
• #5074 – Switching from Sequence mode to Snake mode and back shifts visible area of canvas beyond visible frame. Forever.
• #5121 – Copy does not work in the Firefox browse
• #5335 - The application crashes when selecting Enhanced Stereochemistry from the right-click menu

GitHub: https://github.com/epam/ketcher/releases/tag/v2.22.0

New features

• #3734 - Displaying modified nucleotide chains in sequence representation
• #3824 - Modify nucleotides from sequence in RNA builder
• #4374 - RNA builder should be highlighted in Edit mode. Canvas should be disabled
• #3894 - Paste from clipboard in sequence mode

Bugfixes and improvements

• #4238 - getKet function return ket file without selection flags
• #4174 - Buttons in paste from clipboard window change their position when zoomed more than 175 percent
• #4172 - 'leavingGroup' section does not contain information about number of atoms
• #4144 - Connection of bond to atom inside s-group supergroup cause it connected incorrectly in terms of layout
• #3986 - Selected RNA preset not discards when mouse moved
• #3957 - Atom Query feature export System lost MOST Substitution count values export to Molfile
• #4356 - Clear canvas button doesn't work in Sequence mode
• #4454 - 'Update sequence' modal window: don't close RNA-builder after pressing 'Cancel' in modal window.
• #4455 - 'Update sequence' modal window: display the number of nucleotides to be changed
• #3919 - After pressing Snake mode, attachment points stick out in different directions and not attached to the bonds
• #3899 - Attachment points do not disappear when hover is removed from some monomers.
• #4487 - RNA builder: Cancel button doesn't work
• #4507 - When expanding structures, added to the canvas via Clipboard, an error appears in the Console
• #3843 - System doesn't filter out and do execute html tags and javascript in custom query feature text
• #3816 - RNA Builder allows creating an invalid preset with disconnected sugar
• #4399 - Different chains shown by the same sequence in sequence mode (system ignores sugar presence)
• #4405 - Switching to Sequence mode causes page freeze
• #4568 - Pasted sequences are not visible in the Snake mode
• #4548 - Cyclic chains disappear from canvas when try to Edit in the sequence mode
• #4508 - In the Text-editing mode, when selecting nucleotides linked through phosphates R2-R2, an error appears in the Console
• #4871 - Migrate to Indigo v1.20.0 in-browser module

New main features

• #3650 - Remove and insert nucleotides in sequences (sequence representation)
• #3861 - Insertion mode for nucleotide entry (switch RNA/DNA/Peptide)
• #4146 - UI for Open/Save As FASTA
• #4109 - UI for Save As Sequence
• #3819 - Selection in sequence representation for view mode
• #3819 - Selection in sequence representation edit mode
• #3876 - Nucleotide preview in sequence representation

Bugfixes and improvements

• #3005 - Unable to 'undo' the paste action, if there is no reset to Select tool
• #3902 - If open a macro file and put in center of canvas in micro mode then switch to macro, structure is not in center of canvas*
• #3750 - Add search menu clear button
• #4173 - the pop-up window does not appear in fullscreen mode after clicking the “Open” button and the “Save as” button
• #4231 - Maximum call stack size exceeded error appears during snake layout for large chains
• #3663 - After clicking the 'Duplicate and Edit' button and subsequently clicking 'Cancel,' the preset remains saved.
• #4241 - Pasting large cyclodextrins structure cause Ketcher to freeze
• #4271 - The Uncaught TypeError appears in the DevTool Console, when scrolling until it stops, using the Shift+Left arrow, in the Text-editing mode
• #4295 - Cannot save FASTA using the Remote mode
• #4286 - Editing grid disappears but editing mode is on
• #4297 - When removing nucleotides from the canvas, the preview of the nucleotide does not disappear, if you leave the cursor over it
• #4192 - Export to SVG/PNG ignores "Show hydrogen labels" option
• #3775 - Phenylalanine mustard is displayed incorrectly in the Structure library
• #4296 - When pressing the Enter or the Spacebar, the “Edit mode” drop-down opens and closes randomly in the Text-editing mode
• #4028 - When monomers are selected Del and Backspace hotkey delete selected monomers and switches to Erase tool
• #4356 - Clear canvas button doesn't work in Sequence mode
• #4369 - Del button works as Backspace button that is wrong
• #4329 - Cyclic chains disappear from canvas when switching to sequence mode
• #4252 - Migrate to Indigo v1.19.0 in-browser module